Recent and Upcoming Events

Zoom Meeting

 

November 29-30, 2021

NIH COBRE EAC/IAC Mentor Zoom Meeting

Zoom Conference
Schedule Pending

An annual gathering of ICEMHH external and internal advisory committees, external and internal mentors, principal investigators, research project leaders, pilot project investigators, core leaders, and project support members to discuss the progress and goals of the Integrative Center for Environmental Microbiomes and Human Health (ICEMHH).

Please contact microbre@hawaii.edu for more information.

November 2021

Advertising for a MICRO Core Faculty Position

The University of Hawai'i at Mānoa is currently advertising a position for a new faculty member who is skilled at using advanced imaging techniques in their research. A main responsibility of this position will be to serve as Core Leader for the ICEMMH MICRO facilities Core.

Please contact microbre@hawaii.edu for more information.

November 10, 2021

PhD Dissertation Defense - Adaptative Functions of Sensory and Behavior Laterality in Astyanax Mexicanus

Zoom Meeting
1:00 - 2:00 PM HST

Please contact Masato Yoshizawa (yoshizaw@hawaii.edu) for more information and the Zoom link.

Zoom Meeting

 

November 8, 2021

MS Proposal Seminar - Metabolite Analysis using Direct Analysis in Real Time Mass-Spectrometry

Zoom Meeting
10:00 AM HST

The seminar will address the development of mass spectrometry-based methods for the analysis of amino acids and other small molecules from biological samples.

Please contact Nicolas Cetraro (ncetraro@hawaii.edu) or Joanne Yew (jyew@hawaii.edu) for a Zoom link.

July 26, 2021

Reverse-engineering Drosophila action selection and movement control

Zoom Meeting or Life Sciences Building 109
1:00 PM HST

A shared goal of neuroscience and robotics is to understand how systems can be built to move effectively through the world. However, state-of-the-art algorithms for selecting and executing limbed behaviors in robots are still quite primitive compared with those used by animals. To inform robotic control approaches, we are investigating how the fly, Drosophila melanogaster, controls complex limb movements. I will discuss how we are combining 2-photon imaging of the ventral nerve cord in behaving Drosophila with physics-based simulations and neural network modeling to uncover how flies generate flexible behaviors. Lab website: https://ramdya-lab.epfl.ch/

May 28, 2021

Doctoral Defense Presentation - Drivers of variation in Aedes albopictus and its microbiome at various scales in Hawai`i

Zoom Meeting
1:00 PM HST

The microbiome can influence several physiological traits of mosquitoes including immune regulation, nutrition uptake, and metabolism. The microbiome can even alter a mosquito’s ability to transmit disease (i.e., vector capability), which is likely associated with direct or indirect interactions between the mosquito microbiome and host-residing pathogens. Previous studies have shown that the mosquito microbiome can vary significantly between and within mosquito species due to numerous factors such as diverse ecological habitats, maternal transmission, and complex interactions between microorganisms that co-occur within a host. While there have been studies characterizing the microbiome of some medically-important mosquitoes, the specific environmental and ecological factors that may contribute to mosquito microbiome diversity remain poorly understood.

 

To address the gaps in the existing knowledge of mosquito microbiome for disease-prevention strategies, I centered my research around understanding how specific environmental and ecological factors influence the diversity in the bacterial microbiome of the Aedes albopictus mosquito. Aedes albopictus is widespread throughout Hawai’i, and is a major vector of the Dengue virus and the rapidly emerging Chikungunya virus. I sought to assess how the microbiome varied across a landscape, and amongst distinct mosquito tissues and co-occurring microorganisms. To conduct my research, I collected over 1,000 mosquitoes across the island of Maui and in Mānoa Valley on Oʻahu over a three-year period. I then characterized the Aedes albopictus microbiome and bacterial diversity using DNA sequencing that targeted a bacterial gene (16S ribosomal DNA) containing conserved regions across taxa as well as highly variable regions which are species-specific. Performing comprehensive studies on mosquito microbiomes has the potential to improve strategies for disease preventions that utilize microorganisms to create mosquitoes incapable of transmitting disease; Thus, improving human health and reducing the number of mosquito-related deaths.

Please contact Priscilla Seabourn (pseabour@hawaii.edu) for a Zoom link.

Zoom Meeting

 

November 30 - December 1, 2020

NIH COBRE EAC/IAC Mentor Zoom Meeting

Zoom Conference
7:00 AM - 12:30 PM HST (Nov. 30)
7:00 AM - 11:45 AM HST (Dec. 1)

An annual gathering of ICEMHH external and internal advisory committees, external and internal mentors, principal investigators, research project leaders, pilot project investigators, core leaders, and project support members to discuss the progress and goals of the Integrative Center for Environmental Microbiomes and Human Health (ICEMHH)

Zoom Meeting

 

November 9, 2020

NIH COBRE IAC Zoom Meeting

Zoom Conference
9:00 - 11: 00 HST

An annual gathering with the internal advisory committee to discuss the progress and goals of the Integrative Center for Environmental Microbiomes and Human Health (ICEMHH).

August 2020

Move to the UHM Life Sciences Building


The 3 COBRE ICEMHH core facilities and individual research laboratories will complete the move to the new Life Sciences Building on the UHM campus.

https://www.hawaii.edu/news/2020/06/22/life-sciences-building-new-era/

February 28, 2020

Structural Insights into Fungal and Microbial Two-Component Signaling Pathways - Ann West

Kewalo Marine Laboratory Library
3:30 - 4:30 PM HST

Reversible phosphorylation of proteins involved in signal transduction pathways is a common form of regulation in all three domains of life. A His-to-Asp phosphorelay system in the model organism, Baker's yeast Saccharomyces cerevisiae, allows cells to respond and adapt to a variety of environmental stresses, such as hyperosmotic and oxidative stress conditions. The first part of the seminar will highlight how knowledge of three-dimensional structures of fungal and bacterial two-component signaling proteins can provide unique insight into protein function, the role of phosphorylation, protein-protein interactions, and signaling fidelity. Since homologs of these signaling proteins are not found in mammals, fundamental studies of these pathway components are expected to provide a basis for future development of antimicrobial and/or antifungal therapeutic agents. The second part of the seminar will focus on the Oklahoma COBRE in Structural Biology, for which I have been director for the last 8 years. Some of our successes and challenges from a program administration perspective as well as from a junior faculty career development perspective will be presented.

For further information contact Dr. Joanne Yew, jyew@hawaii.edu.

February 24, 2020

An Enigma of 65 Years: Glucose-Sensing Neurons - Greg Suh

Agricultural Science 219
4:00 - 5:00 PM HST

Glucose-sensing neurons regulate neuronal activity in response to glucose or its metabolite. According to glucostatic hypothesis proposed by Jean Mayer in 1953, feeding is regulated by neurons in the brain that sense glucose levels in the blood. Despite of subsequent discovery of glucose-sensing neurons through electrophysiological approaches by Oomura et al (Nature 1963), the physiological role of glucose sensing in feeding or any related event remains unclear.
I will discuss two types of glucose-sensing neurons in my talk: 1) a population that mediates carbohydrate consumption in animals - flies and mice (Dus et al, Nature Neuroscience 2013, Neuron 2015); 2) a population that regulates the release of insulin and glucagon in flies (Oh et al, Nature 2019).

For further information contact Dr. Joanne Yew, jyew@hawaii.edu.

February 5-13, 2020

Leica THUNDER Computational Clearing Workshop - Jen Lee and Craig Peterson

Agricultural Science 219
10:00 - 11:00 AM HST

The PBRC Biological Electron Microscope Facility will be hosting a Leica THUNDER Computational Clearing Workshop at the University of Hawaiʻi at Mānoa, February 5-13 (see flyer for details). THUNDER Computational Clearing is a Leica-developed technology that instantly removes the haze inherent to thick 3D samples acquired using widefield microscopy. To see a range of different samples and applications, please check out the recently updated gallery of THUNDER images.

There will also be an opportunity to demo the THUNDER technology in person Feb. 5-13 in Snyder Hall Room 118. You can sign up for a demo slot here.

Leica will be bringing 2 systems to the Mānoa campus:
1) The 3D Cell Culture THUNDER Imager, based on the fully motorized DMi8 inverted research microscope. It is ideal for cell culture, tissues, fixed samples, and cleared tissues.
2) The Model Organism THUNDER Imager, based on the M205 FCA stereomicroscope, is intended to image embryos such as zebrafish, Xenopus, mice, C. elegans, as well as whole organs.

For further information contact Tina Weatherby Carvalho, tinacarv@hawaii.edu or Dr. Marilyn Dunlap, mdunlap@hawaii.edu.

January 23, 2020

Listening to the Microbes' Song - Lita Proctor

UH Mānoa Art Building Auditorium
6:30 PM HST

Trained in oceanography, molecular genetics, and microbial ecology, Lita Proctor will speak about how new microbiome research is transforming our understanding of ecosystems, evolution, and human health.

December 4-6, 2019

NIH COBRE EAC/IAC Mentor Meeting

UH Mānoa Campus - Various Locations

An annual gathering of ICEMHH external and internal advisory committees, external and internal mentors, principal and junior investigators, core leaders, and project support members to discuss the progress and goals of the Integrative Center for Environmental Microbiomes and Human Health (ICEMHH).