In the Jani lab, we study the composition, function, and resilience of microbial communities. We focus on basic science that can inform applied needs in human health, wildlife conservation, and environmental sustainability. Our ICEMHH research examines the interactions between infectious pathogens, the microbiome, and environmental change. The microbiomes of animals are frequently faced with disturbances – such as antibiotics, stress, dietary shifts, or infection – that can change the species composition and function of the microbiome. These microbiome shifts can have harmful or beneficial effects on microbiome function and host health. Yet, we lack a comprehensive understanding of what determines the microbiome’s capacity to resist change (resistance) or to recover after disturbance (resilience). Our ICEMHH project leverages the laboratory model Drosophila melanogaster, the naturally diverse Hawaiian Drosophila, and the dramatic environmental gradients of Hawai‘i to achieve research that is both tractable and ecologically realistic. The goal of this work is to understand the drivers of microbiome stability and resilience when faced with the combined impacts of infectious disease and a changing climate.