Recent and Upcoming Events

Structural Insights into Fungal and Microbial Two-Component Signaling

February 28, 2020

Structural Insights into Fungal and Microbial Two-Component Signaling Pathways - Ann West
Kewalo Marine Laboratory Library
3:30 - 4:30 PM

Reversible phosphorylation of proteins involved in signal transduction pathways is a common form of regulation in all three domains of life. A His-to-Asp phosphorelay system in the model organism, Baker's yeast Saccharomyces cerevisiae, allows cells to respond and adapt to a variety of environmental stresses, such as hyperosmotic and oxidative stress conditions. The first part of the seminar will highlight how knowledge of three-dimensional structures of fungal and bacterial two-component signaling proteins can provide unique insight into protein function, the role of phosphorylation, protein-protein interactions, and signaling fidelity. Since homologs of these signaling proteins are not found in mammals, fundamental studies of these pathway components are expected to provide a basis for future development of antimicrobial and/or antifungal therapeutic agents. The second part of the seminar will focus on the Oklahoma COBRE in Structural Biology, for which I have been director for the last 8 years. Some of our successes and challenges from a program administration perspective as well as from a junior faculty career development perspective will be presented.

For further information contact Dr. Joanne Yew, jyew@hawaii.edu

February 24, 2020

An Enigma of 65 Years: Glucose-Sensing Neurons - Greg Suh
Agricultural Science 219
4:00 - 5:00 PM

Glucose-sensing neurons regulate neuronal activity in response to glucose or its metabolite. According to glucostatic hypothesis proposed by Jean Mayer in 1953, feeding is regulated by neurons in the brain that sense glucose levels in the blood. Despite of subsequent discovery of glucose-sensing neurons through electrophysiological approaches by Oomura et al (Nature 1963), the physiological role of glucose sensing in feeding or any related event remains unclear.
I will discuss two types of glucose-sensing neurons in my talk: 1) a population that mediates carbohydrate consumption in animals - flies and mice (Dus et al, Nature Neuroscience 2013, Neuron 2015); 2) a population that regulates the release of insulin and glucagon in flies (Oh et al, Nature 2019).

For further information contact Dr. Joanne Yew, jyew@hawaii.edu

February 5-13, 2020

Leica THUNDER Computational Clearing Workshop - Jen Lee and Craig Peterson
Agricultural Science 219
10:00 - 11:00 AM

The PBRC Biological Electron Microscope Facility will be hosting a Leica THUNDER Computational Clearing Workshop at the University of Hawaiʻi at Mānoa, February 5-13 (see flyer for details). THUNDER Computational Clearing is a Leica-developed technology that instantly removes the haze inherent to thick 3D samples acquired using widefield microscopy. To see a range of different samples and applications, please check out the recently updated gallery of THUNDER images.

There will also be an opportunity to demo the THUNDER technology in person Feb. 5-13 in Snyder Hall Room 118. You can sign up for a demo slot here.

Leica will be bringing 2 systems to the Mānoa campus:
1) The 3D Cell Culture THUNDER Imager, based on the fully motorized DMi8 inverted research microscope. It is ideal for cell culture, tissues, fixed samples, and cleared tissues.
2) The Model Organism THUNDER Imager, based on the M205 FCA stereomicroscope, is intended to image embryos such as zebrafish, Xenopus, mice, C. elegans, as well as whole organs.

For further information contact Tina Weatherby Carvalho, tinacarv@hawaii.edu or Dr. Marilyn Dunlap, mdunlap@hawaii.edu

January 23, 2020

Listening to the Microbes' Song - Lita Proctor
UH Mānoa Art Building Auditorium
6:30 PM

Trained in oceanography, molecular genetics, and microbial ecology, Lita Proctor will speak about how new microbiome research is transforming our understanding of ecosystems, evolution, and human health.

All ICEMHH People

December 4-6, 2019

NIH COBRE EAC/IAC Mentor Meeting
UH Mānoa Campus - Various Locations

An annual gathering of ICEMHH external and internal advisory committees, external and internal mentors, principal and junior investigators, core leaders, and project support members to discuss the progress and goals of the Integrative Center for Environmental Microbiomes and Human Health (ICEMHH)